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TOXICITY ASSESSMENT UNIT

The scope of activities:
− assessment of teratogenic effects of chemical substances, as well as of their impact on reproduction and postnatal development of animals,
− assessment of neurotoxic effects of chemical substances based on the results of a battery of behavioral tests,
− determination of physicochemical parameters of distribution coefficients and kinetic processes of accretion and atrophy in organs of experimental animals,
− development of toxicokinetic models (Physiologically Based Pharmacokinetics) based on the transformation of investigated compounds in  in vitro and in vivo experiments,
− isolation and identification of chemical substance metabolites excreted in urine and in exhaled air.

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