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Selenium in early life to enhance neurodevelopment in unfavourable settings SELENIUS

This project is under the call JPI HDHL Joint Action: Nutrition and Cognitive Function (NutriCog)
The proposal aims at evaluating the specific role of selenium (Se) in relation to other nutrients and trace elements in favouring brain and behavioural plasticity. The central hypothesis we will test is the role of oxidative stress and inflammation as key processes connecting diet, peripheral tissues and brain development. Two isocaloric diets differing in Se content will be given to pregnant and lactating female rats and to their offspring till adulthood. The role of Se in supporting brain and behaviour development will be also assessed in presence of lead (Pb) an environmental stressor able to affect cognitive development that is a concern in some European countries. The project has been organized in 5 work packages aimed at dissecting the effects of the different diets on behavioural development, cognitive functions, hippocampal synaptic plasticity and  peripheral and central inflammation, using. ex vivo and in vitro approaches and transcriptomic, proteomic, metabolomics/lipidomic, measurement of oxidative stress and inflammatory pathways in different target organs. The offspring of the two sexes at different ages will be separately considered to emphasize sex-differences in neurodevelopment. The experimental studies will be reinforced by the observation obtained from an ongoing EU human birth cohort where exposure to Pb, micronutrients, lifestyle have been measured in children in association with assessment of cognitive, language and motor development.

Duration of the project: 04.04.2016 - 03.04.2019
Project coordinator: Istituto Superiore di Sanità, Italy
Head of the NIOM team involved in the project realization: Kinga Polańska, PhD: Kinga.Polanska@imp.lodz.pl


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